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KMID : 0525720110160010015
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Journal of Chitin and Chitosan
2011 Volume.16 No. 1 p.15 ~ p.22
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Synthesis of Multicolored Chitosan-Qdot for Biomedical Marker
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Kwon Jin-Kyung
Kang Ik-Joong
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Abstract
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Recently, many studies have been done in attempts to incorporate quantum dots (QD) into polymeric micro-beads in order to render them water soluble, chemically stable, and biocompatible in physiological media. Luminescent quantum dots have ideal optical properties and have been used to tag chitosan nanoparticles for bio-detection and bio-imaging. While these micro-beads are generally very useful for multiplexed immunoassays, they are not suitable for the staining or labeling of sub-cellular components or intracellular measurements, as they are relatively large in size. As an MPA-capped QD can be placed on the outermost layer of chitosan nanoparticles, the carboxyl group of a QD can be chemically bonded to the amine groups on a chitosan. This method can be extended to the encapsulation of chitosans with multicolored QDs and other colloidal nanocrystals. In this study, we show by UV-Vis absorption, Photolumines- cence spectroscopy, SEM, TEM, and AFM analysis that chitosan-QD nanoparticles can be synthesized easily and successfully. Chitosan-QD nanoparticles with a multicolored QD can be applied to drug delivery systems (DDS) and biomedical markers.
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KEYWORD
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chitosan, multicolored QDs, biomedical marker
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